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KMID : 0356920080550040479
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Korean Journal of Anesthesiology
2008 Volume.55 No. 4 p.479 ~ p.484
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Changes in hemodynamic parameters and regional myocardial perfusion measured by thermal diffusion probe from the infusion of norepinephrine during displacement of porcine beating heart
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Lee Jong-Wha
Park Han-Ki
Bang Sou-Ouk
Kwak Young-Lan
Hong Yong-Woo
Ahn Ji-Woon
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Abstract
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Background: This study was done to evaluate the sole effect of norepinephrine on the regional myocardial perfusion during displacement of the porcine beating heart using thermal diffusion method.
Methods: Thermal diffusion probe was inserted into the anterior myocardial wall during 20 procedures in 10 male pigs (30?35 kg). The measurements of regional myocardial perfusion and hemodynamic parameters were performed after complete instrumentation (baseline), after displacement of the beating heart anteriorly, and 5 and 15 minutes after norepinephrine infusion, titrated to restore baseline mean arterial pressure (MAP).
Results: Norepinephrine infusion reversed the decrease in MAP and myocardial perfusion, caused by displacement of the beating heart (62 ± 3% to 115 ± 4% of baseline, P ＜ 0.01; 41 ± 5% to 125 ± 4% of baseline, P ＜ 0.05, respectively).
Conclusions: Restoration of MAP with norepinephrine infusion without any preload augmentation reversed deterioration in regional myocardial perfusion during displacement of the porcine beating heart.
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KEYWORD
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myocardial perfusion, norepinephrin, off-pump coronary artery bypass graft
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